Ttc21b Is Required in Bergmann Glia for Proper Granule Cell Radial Migration.

ABSTRACT: Proper cerebellar development is dependent on tightly regulated proliferation, migration, and differentiation events. Disruptions in any of these leads to a range of cerebellar phenotypes from ataxia to childhood tumors. Animal models have shown that proper regulation of sonic hedgehog (Shh) signaling is crucial for normal cerebellar architecture, and increased signaling leads to cerebellar tumor formation. Primary cilia are known to be required for the proper regulation of multiple developmental signaling pathways, including Shh. Tetratricopeptide Repeat Domain 21B (Ttc21b) is required for proper primary cilia form and function, and is primarily thought to restrict Shh signaling. Here we investigated a role for Ttc21b in cerebellar developm

SUBMITTER: Driver AM 

PROVIDER: S-EPMC5831799 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature