Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy.

ABSTRACT: In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases. As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation. Identification of the key autophagy targets is essential for the development of new therapeutic agents. Despite this great potential, no therapies are currently available that specifically focus on autophagy modulation. Although drugs like rapamycin, chloroquine

SUBMITTER: Marinkovic M 

PROVIDER: S-EPMC5831833 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature