Electrochemical and AFM Characterization of G-Quadruplex Electrochemical Biosensors and Applications.

ABSTRACT: Guanine-rich DNA sequences are able to form G-quadruplexes, being involved in important biological processes and representing smart self-assembling nanomaterials that are increasingly used in DNA nanotechnology and biosensor technology. G-quadruplex electrochemical biosensors have received particular attention, since the electrochemical response is particularly sensitive to the DNA structural changes from single-stranded, double-stranded, or hairpin into a G-quadruplex configuration. Furthermore, the development of an increased number of G-quadruplex aptamers that combine the G-quadruplex stiffness and self-assembling versatility with the aptamer high specificity of binding to a variety of molecular targets allowed the construction of biosensors with increased selectivity and sensitivity.

SUBMITTER: Chiorcea-Paquim AM 

PROVIDER: S-EPMC5831849 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature