Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension.

ABSTRACT: Primary hypertension is widely believed to be a complex polygenic disorder with the manifestation influenced by the interactions of genomic and environmental factors making identification of susceptibility genes a major challenge. With major advancement in high-throughput genotyping technology, genome-wide association study (GWAS) has become a powerful tool for researchers studying genetically complex diseases. GWASs work through revealing links between DNA sequence variation and a disease or trait with biomedical importance. The human genome is a very long DNA sequence which consists of billions of nucleotides arranged in a unique way. A single base-pair change in the DNA sequence is known as a single nucleotide polymorphism (SNP). With the help of modern genotyping techniques such as chi

SUBMITTER: Azam AB 

PROVIDER: S-EPMC5831899 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature