Effect of Particulate Matter Air Pollution on Cardiovascular Oxidative Stress Pathways.

ABSTRACT: SIGNIFICANCE:Particulate matter (PM) air pollution is a leading cause of global cardiovascular morbidity and mortality. Understanding the biological action of PM is of particular importance in improvement of public health. Recent Advances: Both fine (PM <2.5 μM) and ultrafine particles (<0.1 μM) are widely believed to mediate their effects through redox regulated pathways. A rather simplistic graded ramp model of redox stress has been replaced by a more sophisticated understanding of the role of oxidative stress in signaling, and the realization that many of the observed effects may involve disruption and/or enhancement of normal endogenous redox signaling and induction of a potent immune-mediated response, through entrainment of multiple reactive oxygen species (ROS). CRITICAL ISSUES:The

SUBMITTER: Rao X 

PROVIDER: S-EPMC5831906 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature