The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS.

ABSTRACT:

Introduction

The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS). We studied this intervention.

Methods

We included 48 ALS patients randomized in 2 groups: G1 (n = 24), exercise intensity leveled by CPET; G2 (n = 24), standard care limited by fatigue, during 6 months. ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission (T1) and 6 months later (T2). We registered oxygen uptake, carbon dioxide output, and ventilation at anaerobic threshold and at peak effort. Primary outcome was functional change. We used parametric statistics for comparisons and multiple regression analyses to id

SUBMITTER: Braga ACM 

PROVIDER: S-EPMC5832023 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature