Protective humoral and CD4⁺ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model.

ABSTRACT: Staphylococcus aureus can cause different types of diseases from mild skin infections to life-threatening sepsis worldwide. Owing to the emergence and transmission of multidrug-resistant strains, developing an impactful immunotherapy especially vaccine control approach against S. aureus infections is increasingly encouraged and supported. S. aureus manganese transport protein C (MntC), which is a highly-conserved cell surface protein, can elicit protective immunity against S. aureus and Staphylococcus epidermidis. In this study, we evaluated the humoral immune response and CD4⁺ T cell-mediated immune responses in a mouse peritonitis model. The results showed that MntC-specific antibodies conferred an essential protection for mice to reduce invasion of S. aureus, which was corrob

SUBMITTER: Yu W 

PROVIDER: S-EPMC5832154 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature