Optimization of culture conditions for the derivation and propagation of baboon (Papio anubis) induced pluripotent stem cells.

ABSTRACT: Induced pluripotent stem cells (iPSCs) offer the possibility of cell replacement therapies using patient-matched cells to treat otherwise intractable diseases and debilitations. To successfully realize this potential, several factors must be optimized including i) selection of the appropriate cell type and numbers to transplant, ii) determination of the means of transplantation and the location into which the transplanted cells should be delivered, and iii) demonstration of the safety and efficacy of the cell replacement protocol to mitigate each targeted disease state. A majority of diseases or debilitations likely to be targeted by cell-based therapeutic approaches represent complex conditions or physiologies manifest predominantly in primates including humans. Nonhuman primates afford t

SUBMITTER: Navara CS 

PROVIDER: S-EPMC5832232 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature