Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China.

ABSTRACT:

Background/aims

Methylation status plays a causal role in carcinogenesis in targeted tissues. However, the relationship between the DNA methylation status of multiple genes in blood leukocytes and colorectal cancer (CRC) susceptibility as well as interactions between dietary factors and CRC risks are unclear.

Methods

We performed a case-control study with 466 CRC patients and 507 cancer-free controls to investigate the association among the methylation status of individual genes, multiple CpG site methylation (MCSM), multiple CpG site heterogeneous methylation and CRC susceptibility. Peripheral blood DNA methylation levels were detected by performing methylation-sensitive high-resolution melting.

Results

Total heterogeneous methylation of CA10 and WT1 co

SUBMITTER: Gao HL 

PROVIDER: S-EPMC5832342 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature