Premanifest Huntington's disease: Examination of oculomotor abnormalities in clinical practice.

ABSTRACT:

Introduction

Different oculomotor abnormalities have been reported to occur in premanifest Huntington's disease. The aim of this study is to investigate which oculomotor items of the Unified Huntington's Disease Rating Scale (UHDRS) are affected in premanifest individuals compared to healthy controls, and if CAG repeat length and age are correlated with oculomotor abnormalities in premanifest Huntington's disease gene carriers.

Methods

We compared baseline data of 70 premanifest individuals and 27 controls who participated in the Enroll-HD study at the Leiden University Medical Center, the Netherlands. Premanifest gene carriers were divided in individuals near to disease onset and individuals far from disease onset.

Results

Using a logistic regression model, only hori

SUBMITTER: Winder JY 

PROVIDER: S-EPMC5832368 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature