Liver Dysfunction during Pregnancy and Its Association of With Preterm Birth in China: A Prospective Cohort Study.

ABSTRACT:

Background

Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear.

Methods

A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between January 1, 2012, and June 30, 2016. Liver function tests (LFTs) were monitored through pregnancy. The primary outcomes were PTB and very PTB (delivery prior 37 and 32weeks' gestation respectively). Poisson regression was used to estimate adjusted risk ratios (RR) for women with HBV infection and LFT abnormalities.

Results

Among 36,755 pregnant women (1,113 HBV carriers and 35,642 non-HBV subjects), 3,519 (9.57%) had abnormal LFTs. The commonest cause for liv

SUBMITTER: Zhuang X 

PROVIDER: S-EPMC5832609 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature