Clinical profile of patients with paraneoplastic neuromyelitis optica spectrum disorder and aquaporin-4 antibodies.

ABSTRACT:

Background

In a minority of patients with neuromyelitis optica spectrum disorder (NMOSD) and aquaporin-4 antibodies (AQP4-IgG), the disease has a paraneoplastic origin. It is unknown whether these patients have distinctive clinical features.

Objective

To report the clinical features of a series of patients with paraneoplastic NMOSD and AQP4-IgG and to review previously reported cases.

Methods

Retrospective analysis of clinical records of 156 patients with NMOSD and AQP4-IgG and review of previously reported patients with paraneoplastic NMOSD and AQP4-IgG. Paraneoplastic patients were defined as those with cancer identified within 2 years of the diagnosis of NMOSD.

Results

Five (3.2%) of 156 patients had paraneoplastic NMOSD, and 12 previously reported patients

SUBMITTER: Sepulveda M 

PROVIDER: S-EPMC5832634 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature