Genetic variants in two pathways influence serum urate levels and gout risk: a systematic pathway analysis.

ABSTRACT: The aims of this study were to identify candidate pathways associated with serum urate and to explore the genetic effect of those pathways on the risk of gout. Pathway analysis of the loci identified in genome-wide association studies (GWASs) showed that the ion transmembrane transporter activity pathway (GO: 0015075) and the secondary active transmembrane transporter activity pathway (GO: 0015291) were both associated with serum urate concentrations, with P_FDR values of 0.004 and 0.007, respectively. In a Chinese population of 4,332 individuals, the two pathways were also found to be associated with serum urate (P_FDR = 1.88E-05 and 3.44E-04, separately). In addition, these two pathways were further associated with the pathogenesis of gout (P_FDR = 1.08E-08

SUBMITTER: Dong Z 

PROVIDER: S-EPMC5832812 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature