Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice.

ABSTRACT: Sigma-1 receptor (σ₁R) knockout (KO) CD1 mice, generated by homologous recombination, and separate pharmacological studies in wild type (WT) mice were done to investigate the role of this receptor in the development of pain-related behaviours (thermal hyperalgesia and mechanical allodynia) in mice after spinal cord contusion injury (SCI) - a model of central neuropathic pain. The modulatory effect of σ₁R KO on extracellular mediators and signalling pathways in the spinal cord was also investigated. In particular, changes in the expression of inflammatory cytokines (tumour necrosis factor TNF-α, interleukin IL-1β) and both the expression and activation (phosphorylation) of the N-methyl-D-aspartate receptor subunit 2B (NR2B-NMDA) and extracellular signal-regulated kinas

SUBMITTER: Castany S 

PROVIDER: S-EPMC5832850 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature