Novel anti-androgen receptor signaling agents: Understanding the mechanisms of resistance.

ABSTRACT: Prostate cancer remains an intractable threat to the lives of men worldwide. Although deaths from prostate cancer (PCa) in the United States have declined in recent years, in other parts of the world Pca mortality is increasing. The introduction of 2nd generation anti-androgen receptor agents into the therapeutic armamentarium for metastatic castration-resistant prostate cancer (mCRPC) has resulted in modestly increased survival advantages as demonstrated by initial clinical trials. However, analysis of the molecular pathways affected by these agents may lead to new insight into mechanisms of resistance that drive mCRPC, including proliferation and survival signaling pathways that are derepressed by maximum repression of androgen signaling. Combination therapies that involve anti-AR signal

SUBMITTER: Karanika S 

PROVIDER: S-EPMC5832885 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature