Temporal gradient during famous face naming is associated with lower cerebral blood flow and gray matter volume in aging.

ABSTRACT:

Objective

Evidence suggests that famous face naming may be a cognitive ability especially sensitive to the early pathological processes of Alzheimer's disease (AD) and that those at risk for AD may demonstrate a Ribot temporal gradient (RTG), characterized by better performance for naming remote famous faces than for naming recent famous faces. Reductions in cerebral blood flow (CBF) and gray matter volume (GMV) have been implicated in the neuropathological cascade of AD and show utility as biomarkers of AD risk. We examined whether a RTG during famous face naming was associated with lower CBF and/or GMV among a group of cognitively normal older adults.

Methods

Voxel-wise independent samples t-tests were employed to contrast resting CBF values between those who exhibited a R

SUBMITTER: Hays CC 

PROVIDER: S-EPMC5833019 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature