High CD8⁺ and absence of Foxp3⁺ T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival.

ABSTRACT:

Background

Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only effective treatment, and a five-year survival rate of advanced-stage patients is less than 10%. Hence, exploring immunotherapy is relevant, although GBC immunogenicity is poorly understood. This study examined the relationship between the host immune response and GBC patient survival based on the presence of tumor-infiltrating lymphocytes at different disease stages.

Methods

Tumor tissues from 80 GBC patients were analyzed by immunohistochemistry for the presence of CD3⁺, CD4⁺, CD8⁺, and Foxp3⁺ T cell populations, and

SUBMITTER: Fluxa P 

PROVIDER: S-EPMC5833069 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature