<i>SMYD2</i> promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and <i>SMYD2</i> expression in vascular smooth muscle cells.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA) is a deadly cardiovascular disease characterised by the gradual, irreversible dilation of the abdominal aorta. AAA is a complex genetic disease but little is known about the role of epigenetics. Our objective was to determine if global DNA methylation and CpG-specific methylation at known AAA risk loci is associated with AAA, and the functional effects of methylation changes.

Results

We assessed global methylation in peripheral blood mononuclear cell DNA from 92 individuals with AAA and 93 controls using enzyme-linked immunosorbent assays, identifying hyper-methylation in those with large AAA and a positive linear association with AAA diameter (P < 0.0001, R² = 0.3175).We then determined CpG methylation stat

SUBMITTER: Toghill BJ 

PROVIDER: S-EPMC5833080 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature