Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease.

ABSTRACT:

Background

External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year all-cause mortality in mostly multimorbid patients with COPD.

Methods

We relied on 24 cohort studies of the COPD Cohorts Collaborative International Assessment consortium, corresponding to primary, secondary, and tertiary care in Europe, the Americas, and Japan. These studies include globally 15,762 patients with COPD (1871 deaths and 42,203 person years of follow-up). We used network meta-analysis adapted to multiple score comparison (MSC), following a freque

SUBMITTER: Guerra B 

PROVIDER: S-EPMC5833113 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature