Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study.

ABSTRACT:

Background and objective

Current surveillance strategies for colorectal cancer following polypectomy are determined by endoscopic and histopathological factors. Such a distinction has been challenged. The present study was designed to identify molecular parameters in colonic polyps potentially defining new sub-groups at risk.

Methods

One hundred patients were enrolled in this multicentre study. Polyps biopsies underwent formalin-free processing (PAXgene, PreAnalytiX) and targeted next generation sequencing (38 genes (QIAGEN), NextSeq 500 platform (Illumina)). Genetic and histopathological analyses were done blinded to other data.

Results

In 100 patients, 224 polyps were removed. Significant associations of genetic alterations with endoscopic or histological polyp char

SUBMITTER: Berger AW 

PROVIDER: S-EPMC5833231 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature