Reversible Electroporation-Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With ⁸⁹Zr-Labeled Reporter Nanoparticles.

ABSTRACT: Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle (⁸⁹Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered ⁸⁹Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of ⁸⁹Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of ⁸⁹Zr-NRep in tumors. ⁸⁹Zr-NRep and DOX uptake correlated well in both electroporated and control

SUBMITTER: Srimathveeravalli G 

PROVIDER: S-EPMC5833236 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature