In silico analysis of antibiotic-induced Clostridium difficile infection: Remediation techniques and biological adaptations.

ABSTRACT: In this paper we study antibiotic-induced C. difficile infection (CDI), caused by the toxin-producing C. difficile (CD), and implement clinically-inspired simulated treatments in a computational framework that synthesizes a generalized Lotka-Volterra (gLV) model with SIR modeling techniques. The gLV model uses parameters derived from an experimental mouse model, in which the mice are administered antibiotics and subsequently dosed with CD. We numerically identify which of the experimentally measured initial conditions are vulnerable to CD colonization, then formalize the notion of CD susceptibility analytically. We simulate fecal transplantation, a clinically successful treatment for CDI, and discover that both the transplant timing and transplant donor are relevant to the the efficacy of

SUBMITTER: Jones EW 

PROVIDER: S-EPMC5833281 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature