Subcortical Local Functional Hyperconnectivity in Cannabis Dependence.

ABSTRACT:

Background

Cannabis abuse (CA) has been associated with psychopathology, including negative emotionality and higher risk of psychosis, particularly with early age of initiation. However, the mechanisms underlying this association are poorly understood. Because aberrant dopamine signaling is implicated in cannabis-associated psychopathology, we hypothesized that regular CA would be associated with altered resting-state functional connectivity in dopamine midbrain-striatal circuits.

Methods

We examined resting-state brain activity of subcortical regions in 441 young adults from the Human Connectome Project, including 30 subjects with CA meeting DSM-IV criteria for dependence and 30 control subjects matched on age, sex, education, body mass index, anxiety, depression, and alcoh

SUBMITTER: Manza P 

PROVIDER: S-EPMC5833305 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature