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Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD⁺/SIRT1/SUV39H1/H3K9me3 signaling pathway.

ABSTRACT: Norisoboldine (NOR), a natural aryl hydrocarbon receptor (AhR) agonist, has been demonstrated to attenuate ulcerative colitis (UC) and induce the generation of Treg cells. Under UC condition, hypoxia widely exists in colonic mucosa, and secondary changes of microRNAs (miRs) expressions and glycolysis contribute to Treg differentiation. At present, we worked for exploring the deep mechanisms for NOR-promoted Treg differentiation in hypoxia and its subsequent anti-UC action from the angle of AhR/miR or AhR/glycolysis axis. Results showed that NOR promoted Treg differentiation in hypoxia and the effect was stronger relative to normoxia. It activated AhR in CD4⁺ T cells under hypoxic microenvironment; CH223191 (a specific AhR antagonist) and siAhR-3 abolished NOR-promoted Treg diffe

SUBMITTER: Lv Q

PROVIDER: S-EPMC5833367 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Dataset Information

Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD⁺/SIRT1/SUV39H1/H3K9me3 signaling pathway.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD⁺/SIRT1/SUV39H1/H3K9me3 signaling pathway.