TR₄ nuclear receptor suppresses HCC cell invasion via downregulating the EphA2 expression.

ABSTRACT: Early studies indicated that testicular nuclear receptor 4 (TR₄) could function as a suppressor in the transcriptional regulation of the HBV core gene expression, which might then influence the development of hepatocellular carcinoma (HCC). The direct linkage between TR₄ and HCC progression, however, remained unclear. Here, via a human clinical sample survey, we found that 13 of the 18 HCC patients studied had lower TR₄ expression in metastatic lesions than in matched primary HCC lesions, suggesting that TR₄ may play a negative role in HCC metastasis. Results from in vitro cell migration/invasion studied confirmed that TR₄ could suppress HCC cell migration/invasion. Mechanism dissection revealed that TR₄ might function throu

SUBMITTER: Jin R 

PROVIDER: S-EPMC5833398 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature