The interactome and spatial redistribution feature of Ca²⁺ receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion.

ABSTRACT: Numerous studies have shown that calmodulin (CaM) is a major regulator of calcium-dependent signaling, which regulates cell proliferation, programmed cell death, and autophagy in cancer. However, limited information is available on mechanisms underlying the effect of CaM on the invasive property of glioblastoma multiforme (GBM) cells, especially with respect to invadopodia formation. In this study, we find that CaM serves as a prognostic factor for GBM, and it is strongly associated with the invasive nature of this tumor. Results of preliminary experiments indicated that CaM concentration was significantly correlated with the invasive capacity of and invadopodia formation by different GBM cell lines. CaM inhibition via a small hairpin RNA or a pharmacological inhibitor significantly disrup

SUBMITTER: Li T 

PROVIDER: S-EPMC5833463 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature