Blood Pressure Trajectories in the 20 Years Before Death.

ABSTRACT:

Importance

There is mixed evidence that blood pressure (BP) stabilizes or decreases in later life. It is also unclear whether BP trajectories reflect advancing age, proximity to end of life, or selective survival of persons free from hypertension.

Objective

To estimate individual patient BP for each of the 20 years before death and identify potential mechanisms that may explain trajectories.

Design, study, and participants

We analyzed population-based Clinical Practice Research Datalink primary care and linked hospitalization electronic medical records from the United Kingdom, using retrospective cohort approaches with generalized linear mixed-effects modeling. Participants were all available individuals with BP measures over 20 years, yielding 46 634 participants dyi

SUBMITTER: Delgado J 

PROVIDER: S-EPMC5833502 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature