Association of Blood Pressure Lowering With Mortality and Cardiovascular Disease Across Blood Pressure Levels: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

High blood pressure (BP) is the most important risk factor for death and cardiovascular disease (CVD) worldwide. The optimal cutoff for treatment of high BP is debated.

Objective

To assess the association between BP lowering treatment and death and CVD at different BP levels.

Data sources

Previous systematic reviews were identified from PubMed, the Cochrane Database of Systematic Reviews, and the Database of Abstracts of Reviews of Effect. Reference lists of these reviews were searched for randomized clinical trials. Randomized clinical trials published after November 1, 2015, were also searched for in PubMed and the Cochrane Central Register for Controlled Trials during February 2017.

Study selection

Randomized clinical trials with at least 1000 pat

SUBMITTER: Brunstrom M 

PROVIDER: S-EPMC5833509 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature