Association of Salivary MicroRNA Changes With Prolonged Concussion Symptoms.

ABSTRACT:

Importance

Approximately one-third of children who experience a concussion develop prolonged concussion symptoms. To our knowledge, there are currently no objective or easily administered tests for predicting prolonged concussion symptoms. Several studies have identified alterations in epigenetic molecules known as microRNAs (miRNAs) following traumatic brain injury. No studies have examined whether miRNA expression can detect prolonged concussion symptoms.

Objective

To evaluate the efficacy of salivary miRNAs for identifying children with concussion who are at risk for prolonged symptoms.

Design, setting, and participants

This prospective cohort study at the Penn State Medical Center observed 52 patients aged 7 to 21 years presenting for evaluation of concussion with

SUBMITTER: Johnson JJ 

PROVIDER: S-EPMC5833519 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature