Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults.

ABSTRACT:

Importance

Increasing levels of high-density lipoprotein (HDL) cholesterol through pharmacologic inhibition of cholesteryl ester transfer protein (CETP) is a potentially important strategy for prevention and treatment of cardiovascular disease (CVD).

Objective

To use genetic variants in the CETP gene to assess potential risks and benefits of lifelong lower CETP activity on CVD and other outcomes.

Design, setting, and participants

This prospective biobank study included 151 217 individuals aged 30 to 79 years who were enrolled from 5 urban and 5 rural areas of China from June 25, 2004, through July 15, 2008. All participants had baseline genotype data, 17 854 of whom had lipid measurements and 4657 of whom had lipoprotein particle measurements. Median follow-up of 9.2

SUBMITTER: Millwood IY 

PROVIDER: S-EPMC5833522 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature