Association of LPA Variants With Aortic Stenosis: A Large-Scale Study Using Diagnostic and Procedural Codes From Electronic Health Records.

ABSTRACT:

Importance

Elevated lipoprotein(a) levels are a risk factor for aortic stenosis (AS). However, a large-scale replication of associations between LPA variants and AS, their interactions with risk factors, and the effect of multiple risk alleles is not well established.

Objective

To replicate the association between LPA variants with AS and identify subgroups who are at higher risk of developing AS.

Design, setting, and participants

This case-control study of AS included 44 703 individuals (3469 cases) 55 years or older who were enrolled in the Genetic Epidemiology Research on Aging cohort and who were members of the Kaiser Permanente Northern California health care delivery system. The study leveraged the linkage of administrative health data, electronic medical record

SUBMITTER: Chen HY 

PROVIDER: S-EPMC5833523 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature