Induced neural stem cell-derived astrocytes modulate complement activation and mediate neuroprotection following closed head injury.

ABSTRACT: The complement system is a crucial component of immunity, and its activation has critical roles in neuroinflammatory response and cellular damage following closed head injury (CHI). We previously demonstrated that systemically injected induced neural stem cells (iNSCs) could modulate complement activation to ameliorate neuronal apoptosis in mouse CHI models. However, it remains unknown whether iNSC derivatives can regulate complement activation. In the present study, after CHI mouse serum treatment, we found dramatic decreases in the cellular viabilities of differentiated iNSCs. Interestingly, following CHI mouse serum treatment, the death of astrocytes derived from iNSCs which were pre-treated with CHI mouse serum was significantly decreased. Meanwhile, the deposition of C3 (C3d) and C5b-

SUBMITTER: Gao M 

PROVIDER: S-EPMC5833559 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature