Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.

ABSTRACT: Despite the characteristic etiologies and phenotypes, different brain disorders rely on common pathogenic events. Glutamate-induced neurotoxicity is a pathogenic event shared by different brain disorders. Another event occurring in different brain pathological conditions is the increase of the extracellular ATP levels, which is now recognized as a danger and harmful signal in the brain, as heralded by the ability of P2 receptors (P2Rs) to affect a wide range of brain disorders. Yet, how ATP and P2R contribute to neurodegeneration remains poorly defined. For that purpose, we now examined the contribution of extracellular ATP and P2Rs to glutamate-induced neurodegeneration. We found both in vitro and in vivo that ATP/ADP through the activation of P2Y1R contributes to glutamate-induced neuron

SUBMITTER: Simoes AP 

PROVIDER: S-EPMC5833818 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature