Time to surgery and pathologic complete response after neoadjuvant chemoradiation in rectal cancer: A population study on 2094 patients.

ABSTRACT:

Background

To retrospectively evaluate the difference in terms of pathologic complete response (pCR) according to time elapsed between chemoradiation (CRT) and total mesorectal excision (TME) on a large unselected real-life dataset of locally advanced rectal cancer (LARC) patients.

Methods

A multicentre retrospective cohort study of LARC patients from 21 Italian Radiotherapy Institutions was performed. Patients were stratified into 3 different time intervals from CRT. The 1st group included 300 patients who underwent TME within 6 weeks, the 2nd 1598 patients (TME within 7-12 weeks) and the 3rd 196 patients (TME within 13 or more weeks after CRT), respectively.

Results

Data on 2094 LARC patients treated between 1997 and 2016 were considered suitable for analysis. Overa

SUBMITTER: Macchia G 

PROVIDER: S-EPMC5833913 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature