Intravenous Oxycodone versus Intravenous Morphine in Cancer Pain: A Randomized, Open-Label, Parallel-Group, Active-Control Study.

ABSTRACT:

Objective

To compare efficacy and safety of intravenous continuous infusion of oxycodone with morphine in patients with cancer pain.

Methods

A 5-day, randomized, open-label, exploratory study at 6 sites in the Republic of Korea. Sixty-six adults aged ≥19 years with moderate-to-severe cancer pain (Numeric Rating Scale [NRS] ≥ 4) were enrolled. The study group received intravenous (IV) oxycodone, and the comparator group received IV morphine which were titrated depending on pain intensity. The efficacy endpoint is change in average NRS score from baseline to Day 5. Other assessments included worst, current, and average pain intensity; patient satisfaction; medication dose; and adverse events.

Results

Both groups achieved >50% reduction in average pain intensity: from "m

SUBMITTER: Lee KH 

PROVIDER: S-EPMC5833922 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature