TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.

ABSTRACT: Emerging observations link dysregulation of TANK-binding kinase 1 (TBK1) to developmental disorders, inflammatory disease, and cancer. Biochemical mechanisms accounting for direct participation of TBK1 in host defense signaling have been well described. However, the molecular underpinnings of the selective participation of TBK1 in a myriad of additional cell biological systems in normal and pathophysiologic contexts remain poorly understood. To elucidate the context-selective role of TBK1 in cancer cell survival, we employed a combination of broad-scale chemogenomic and interactome discovery strategies to generate data-driven mechanism-of-action hypotheses. This approach uncovered evidence that TBK1 supports AKT/mTORC1 pathway activation and function through direct modulation of multiple p

SUBMITTER: Cooper JM 

PROVIDER: S-EPMC5833933 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature