EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.

ABSTRACT: We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8⁺ T cells primarily through MHCI recycling and cross-dressing. EVIRs should facilitate exploring the mechanisms and implications of horizontal transfer of tumor antigens to antigen-presenting cells.

SUBMITTER: Squadrito ML 

PROVIDER: S-EPMC5833950 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature