Clinical events preceding switching and discontinuation of oral anticoagulant treatment in patients with atrial fibrillation.

ABSTRACT:

Aims

Switching between oral anticoagulants and treatment discontinuation are common events related to therapy with non-vitamin K antagonist oral anticoagulants (NOACs). However, knowledge on the reasons leading to these treatment changes is scarce. The aim of this study was to identify clinical events preceding anticoagulant switching and NOAC discontinuation during oral anticoagulant therapy in patients with atrial fibrillation.

Methods and results

We performed a nationwide register-based study including Danish atrial fibrillation patients initiating a NOAC between August 2011 and February 2016 (n = 50 623). We explored potential reasons leading to changes in anticoagulant treatment by identifying clinical events preceding switches from vitamin K antagonists (VKA) to NOAC,

SUBMITTER: Hellfritzsch M 

PROVIDER: S-EPMC5834049 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature