Comprehensive evaluation of published gene expression prognostic signatures for biomarker-based lung cancer clinical studies.

ABSTRACT:

Background

A more accurate prognosis for non-small-cell lung cancer (NSCLC) patients could aid in the identification of patients at high risk for recurrence. Many NSCLC mRNA expression signatures claiming to be prognostic have been reported in the literature. The goal of this study was to identify the most promising mRNA prognostic signatures in NSCLC for further prospective clinical validation.

Experimental design

We carried out a systematic review and meta-analysis of published mRNA prognostic signatures for resected NSCLC. The prognostic performance of each signature was evaluated via a meta-analysis of 1927 early stage NSCLC patients collected from 15 studies using three evaluation metrics (hazard ratios, concordance scores, and time-dependent receiver-operating characte

SUBMITTER: Tang H 

PROVIDER: S-EPMC5834090 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature