Surgical resection versus watchful waiting in low-grade gliomas.

ABSTRACT:

Background

Infiltrating low-grade gliomas (LGG; WHO grade 2) typically present with seizures in young adults. LGGs grow continuously and usually transform to higher grade of malignancy, eventually causing progressive disability and premature death. The effect of up-front surgery has been controversial and the impact of molecular biology on the effect of surgery is unknown. We now present long-term results of upfront surgical resection compared with watchful waiting in light of recently established molecular markers.

Materials and methods

Population-based parallel cohorts were followed from two Norwegian university hospitals with different surgical treatment strategies and defined geographical catchment regions. In region A watchful waiting was favored while early resection w

SUBMITTER: Jakola AS 

PROVIDER: S-EPMC5834105 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature