Revisiting the definition of estrogen receptor positivity in HER2-negative primary breast cancer.

ABSTRACT:

Background

Although 1% has been used as cut-off for estrogen receptor (ER) positivity, several studies have reported that tumors with ER < 1% have characteristics similar to those with 1% ≤ ER < 10%. We hypothesized that in patients with human epidermal growth factor 2 (HER2)-negative breast cancer, a cut-off of 10% is more useful than one of 1% in discriminating for both a better pathological complete response (pCR) rate to neoadjuvant chemotherapy and a better long-term outcome with adjuvant hormonal therapy. Our objectives were to identify a percentage of ER expression below which pCR was likely and to determine whether this cut-off value can identify patients who would benefit from adjuvant hormonal therapy.

Patients and methods

Patients with stage II or III HER2-negativ

SUBMITTER: Fujii T 

PROVIDER: S-EPMC5834134 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature