The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation.

ABSTRACT: Chromatin remodeling complexes are essential for gene expression programs that coordinate cell function with metabolic status. However, how these remodelers are integrated in metabolic stability pathways is not well known. Here, we report an expansive genetic screen with chromatin remodelers and metabolic regulators in Saccharomyces cerevisiae. We found that, unlike the SWR1 remodeler, the INO80 chromatin remodeling complex is composed of multiple distinct functional subunit modules. We identified a strikingly divergent genetic signature for the Ies6 subunit module that links the INO80 complex to metabolic homeostasis. In particular, mitochondrial maintenance is disrupted in ies6 mutants. INO80 is also needed to communicate TORC1-mediated signaling to chromatin, as ino80 mutants exhibit de

SUBMITTER: Beckwith SL 

PROVIDER: S-EPMC5834206 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature