Novel adherent CD11b⁺ Gr-1⁺ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment.

ABSTRACT: The immunosuppressive tumor microenvironment is a hallmark of cancer. Myeloid-derived suppressor cells (MDSCs) are CD11b⁺ Gr-1⁺ tumor-infiltrating immature myeloid cells that strongly mediate tumor immunosuppression. The CD11b⁺ Gr-1⁺ cells are a heterogeneous cell population, and the impacts of each subpopulation on tumor progression are not yet completely understood. In the present study, we identified a novel subpopulation of CD11b⁺ Gr-1⁺ cells from murine lung carcinoma tumors according to their strongly adherent abilities. Although strong adherent activity is a unique property of macrophages, their marker expression patterns are similar to those of MDSCs; thus, we named this novel subpopulation MDSC-like adherent cells (

SUBMITTER: Tsubaki T 

PROVIDER: S-EPMC5834266 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature