Identification of prefrontal cortex protein alterations in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia in developed countries. A better understanding of the events taking place at the molecular level would help to identify novel protein alterations, which might be used in diagnosis or for treatment development. In this study, we have performed the high-throughput analysis of 706 molecules mostly implicated in cell-cell communication and cell signaling processes by using two antibody microarray platforms. We screened three AD pathological groups -each one containing four pooled samples- from Braak stages IV, V and VI, and three control groups from two healthy subjects, five frontotemporal and two vascular dementia patients onto Panorama and L-Series antibody microarrays to identify AD-specific alterations not common to other dement

SUBMITTER: Garranzo-Asensio M 

PROVIDER: S-EPMC5834268 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature