Pseudo continuous arterial spin labeling quantification in anemic subjects with hyperemic cerebral blood flow.

ABSTRACT: PURPOSE:To investigate possible sources of quantification errors in global cerebral blood flow (CBF) measurements by comparing pseudo continuous arterial spin labeling (PCASL) and phase contrast (PC) MRI in anemic, hyperemic subjects. METHODS:All studies were performed on a Philips 3T Achieva MRI scanner. PC and PCASL CBF examinations were performed in 10 healthy, young adult subjects and 18 young adults with chronic anemia syndromes including sickle cell disease and thalassemia. CBF estimates from single and two compartment ASL kinetic models were compared. Numerical simulation and flow phantom experiments were used to explore the effects of blood velocity and B1+ on CBF quantification and labeling efficiency. RESULTS:PCASL CBF underestimated PC in both populations using a single compartm

SUBMITTER: Bush A 

PROVIDER: S-EPMC5834316 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature