Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies.

ABSTRACT: Cholangiopathies are a diverse group of progressive diseases whose primary cell targets are cholangiocytes. To identify shared pathogenesis and molecular connectivity among the three main human cholangiopathies (biliary atresia [BA], primary biliary cholangitis [PBC], and primary sclerosing cholangitis [PSC]), we built a comprehensive platform of published data on gene variants, gene expression, and functional studies and applied network-based analytics in the search for shared molecular circuits. Mining the data platform with largest connected component and interactome analyses, we validated previously reported associations and identified essential and hub genes. In addition to disease-specific modules, we found a substantial overlap of disease neighborhoods and uncovered a group of 34 co

SUBMITTER: Luo Z 

PROVIDER: S-EPMC5834359 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature