A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation.

ABSTRACT: Several inflammatory diseases including multiple sclerosis and inflammatory bowel disease have been associated with dysfunctional and/or reduced numbers of Foxp3⁺ regulatory T cells (Treg). While numerous mechanisms of action have been discovered by which Treg can exert their function, disease-specific Treg requirements remain largely unknown. We found that the integrin αv, which can pair with several β subunits including β8, is highly upregulated in Treg at sites of inflammation. Using mice that lacked αv expression or β8 expression specifically in Treg, we demonstrate that there was no deficit in Treg accumulation in the central nervous system during experimental autoimmune encephalomyelitis and no difference in the resolution of disease compared to control mice. In contrast,

SUBMITTER: Mair I 

PROVIDER: S-EPMC5834440 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature