Significance of risk polymorphisms for depression depends on stress exposure.

ABSTRACT: Depression is a polygenic and multifactorial disorder where environmental effects exert a significant impact, yet most genetic studies do not consider the effect of stressors which may be one reason for the lack of replicable results in candidate gene studies, GWAS and between human studies and animal models. Relevance of functional polymorphisms in seven candidate genes previously implicated in animal and human studies on a depression-related phenotype given various recent stress exposure levels was assessed with Bayesian relevance analysis in 1682 subjects. This Bayesian analysis indicated a gene-environment interaction whose significance was also tested with a traditional multivariate analysis using general linear models. The investigated genetic factors were only relevant in the modera

SUBMITTER: Gonda X 

PROVIDER: S-EPMC5834495 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature