Temporal-prefrontal cortical network for discrimination of valuable objects in long-term memory.

ABSTRACT: Remembering and discriminating objects based on their previously learned values are essential for goal-directed behaviors. While the cerebral cortex is known to contribute to object recognition, surprisingly little is known about its role in retaining long-term object-value associations. To address this question, we trained macaques to arbitrarily associate small or large rewards with many random fractal objects (>100) and then used fMRI to study the long-term retention of value-based response selectivity across the brain. We found a pronounced long-term value memory in core subregions of temporal and prefrontal cortex where, several months after training, fractals previously associated with high reward ("good" stimuli) elicited elevated fMRI responses compared with those associated with l

SUBMITTER: Ghazizadeh A 

PROVIDER: S-EPMC5834664 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature