Arachidonic acid-induced Ca²⁺ entry and migration in a neuroendocrine cancer cell line.

ABSTRACT:

Background

Store-operated Ca²⁺ entry (SOCE) has been implicated in the migration of some cancer cell lines. The canonical SOCE is defined as the Ca²⁺ entry that occurs in response to near-maximal depletion of Ca²⁺ within the endoplasmic reticulum. Alternatively, arachidonic acid (AA) has been shown to induce Ca²⁺ entry in a store-independent manner through Orai1/Orai3 hetero-multimeric channels. However, the role of this AA-induced Ca²⁺ entry pathway in cancer cell migration has not been adequately assessed.

Methods

The present study investigated the involvement of AA-induced Ca²⁺ entry in migration in BON cells, a model gastro-enteropancreatic neuroendocrine tumor (GEPNET) cell line using pharmacological and

SUBMITTER: Goswamee P 

PROVIDER: S-EPMC5834873 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature